538
76. Franquesa M, Hoogduijn MJ, Bestard O, Grinyo JM
Immunomodulatory effect of mesenchymal stem cells on B
cells. Front Immunol (2012) 3:212.
77. Raffaghello L, Bianchi G, Bertolotto M, Montecucco F, Busca
A, et al Human mesenchymal stem cells inhibit neutrophil
apoptosis: a model for neutrophil preservation in the bone
marrow niche. Stem Cells (2008) 26(1):151–162.
78. Spaggiari GM, Capobianco A, Abdelrazik H, Becchetti F,
Mingari MC, et al Mesenchymal stem cells inhibit natural
killer-cell proliferation, cytotoxicity, and cytokine production:
role of indoleamine 2,3-dioxygenase and prostaglandin E2.
Blood (2008) 111(3):1327–1333.
79. Rahmat Z, Jose S, Ramasamy R, Vidyadaran S Reciprocal
interactions of mouse bone marrow-derived mesenchymal
stem cells and BV2 microglia after lipopolysaccharide
stimulation. Stem Cell Res Ther (2013) 4(1):12.
80. Chang YS, Ahn SY, Jeon HB, Sung DK, Kim ES, et al Critical role of
vascular endothelial growth factor secreted by mesenchymal
stem cells in hyperoxic lung injury. Am J Respir Cell Mol Biol
(2014) 51(3):391–399.
81. Guan XJ, Song L, Han FF, Cui ZL, Chen X, et al Mesenchymal
stem cells protect cigarette smoke-damaged lung and
pulmonary function partly via VEGF-VEGF receptors. J Cell
Biochem (2013) 114(2): 323–335.
82. Gao LR, Zhang NK, Ding QA, Chen HY, Hu X, Jiang S, et al
Common expression of stemness molecular markers and early
cardiac transcription factors in human Wharton’s jellyderived
mesenchymal stem cells and embryonic stem cells. Cell
Transplant (2013) 22(10):1883–1900.
83. Hsieh JY, Wang HW, Chang SJ, Liao KH, Lee IH, Lin WS, et al
Mesenchymal stem cells from human umbilical cord express
preferentially secreted factors related to neuroprotection,
neurogenesis, and angiogenesis. PLoS ONE (2013)
8(8):e72604.
84. Teixeira FG, Carvalho MM, Neves-Carvalho A, Panchalingam
KM, Behie LA, Pinto L, et al AJ Secretome of mesenchymal
progenitors from the umbilical cord acts as modulator of
neural/glial proliferation and differentiation. Stem Cell Rev
(2015) 11(2):288–297
85. Pires AO, Neves-Carvalho A, Sousa N, Salgado AJ The secretome
of bone marrow and Wharton jelly derived mesenchymal stem
cells induces differentiation and neurite outgrowth in SH-SY5Y
cells. Stem Cells Int (2014) 2014: 438352.
86. Constantin G, Marconi S, Rossi B, Angiari S, Calderan L, et al
(Adipose-derived mesenchymal stem cells ameliorate chronic
experimental autoimmune encephalomyelitis. Stem Cells
2009) 27(10):2624–2635.
87. Bai L, Lennon DP, Caplan AI, DeChant A, Hecker J, et al
Hepatocyte growth factor mediates mesenchymal stem cell-
induced recovery in multiple sclerosis models. Nat Neurosci
(2012) 15(6):862– 870.
88. Voulgari-Kokota A, Fairless R, Karamita M, Kyrargyri V, Tseveleki
V, et al Mesenchymal stem cells protect CNS neurons against
glutamate excitotoxicity by inhibiting glutamate recepto
89. Gu W, Zhang F, Xue Q, Ma Z, Lu P, Yu B Transplantation
of bone marrow mesenchymal stem cells reduces lesion
volume and induces axonal regrowth of injured spinal cord.
Neuropathology (2010) 30(3):205–217.
90. Meng F, Meliton A, Moldobaeva N, Mutlu G, Kawasaki Y, et
al Asef mediates HGF protective effects against LPSinduced
lung injury and endothelial barrier dysfunction. Am J Physiol
Lung Cell Mol Physiol (2015) 308(5):L452–L463.
91. Ramalho-Santos M, Willenbring H On the origin of the term
“stem cell”. Cell Stem Cell (2007) 1(1):35–38.
92. Caplan AI Mesenchymal stem cells. J Orthop Res (1991)
9(5):641–650.
93. Nartprayut K, U-Pratya Y, Kheolamai P, Manochantr S,
Chayosumrit M, et al Cardiomyocyte differentiation of
perinatally derived mesenchymal stem cells. Mol Med Rep
(2013) 7(5):1465–1469.
94. Li D, Chai J, Shen C, Han Y, Sun T Human umbilical cord-
derived mesenchymal stem cells differentiate into epidermal-
like cells using a novel co-culture technique. Cytotechnology
(2014) 66(4):699–708.
95. Wu KH, Zhou B, Lu SH, Feng B, Yang SG, et al In vitro and
in vivo differentiation of human umbilical cord derived
stem cells into endothelial cells. J Cell Biochem (2007)
100(3):608–616.
96. Leite C, Silva NT, Mendes S, Ribeiro A, de Faria JP, et al
Differentiation of human umbilical cord matrix mesenchymal
stem cells into neural-like progenitor cells and maturation
into an oligodendroglial-like lineage. PLoS ONE (2014)
9(10):e111059.
97. Yan ZJ, Hu YQ, Zhang HT, Zhang P, Xiao ZY, et alComparison of
the neural differentiation potential of human mesenchymal
stem cells from amniotic fluid and adult bone marrow. Cell
Mol Neurobiol (2013) 33(4):465–475.
98. Mendez JJ, Ghaedi M, Steinbacher D, Niklason LE Epithelial
cell differentiation of human mesenchymal stromal cells in
decellularized lung scaffolds. Tissue Eng Part A(2014) 20(11-
12):1735–1746.
99. Huang K, Kang X, Wang X, Wu S, Xiao J, Li Z, et al Conversion
of bone marrow mesenchymal stem cells into type II alveolar
epithelial cells reduces pulmonary fibrosis by decreasing
oxidative stress in rats. Mol Med Rep (2015) 11(3):1685–
1692.
100. Cerrada A, de la Torre P, Grande J, Haller T, Flores AI, et
al Human decidua-derived mesenchymal stem cells
differentiate into functional alveolar type II-like cells that
synthesize and secrete pulmonary surfactant complexes.
PLoS ONE (2014) 9(10):e110195.
101. Struebe L, Thebaud B, Advances in bronchopulmonary
dysplasia. Expert Rev. Respir. Med.2014; 8(3): 327–338.
102. O’Reilly M, Thebaud B. Using cell-based strategies to break
the link between bronchopulmonary dysplasia and the
development of chronic lung disease in later life. Pulm Med
2013;2013:874161.
[REV. MED. CLIN. CONDES - 2016; 27(4) 529-539]
expression and function. Exp Neurol (2012) 236(1):161–170.