88
Los autores declaran no tener conflictos de interés, en relación a este artículo.
REFERENCIAS BIBLIOGRÁFICAS
1. Pavia A. Viral infections of the lower respiratory tract: Old
viruses, new viruses, and the role of diagnosis. Clin Infect Dis
2011;52 (S4):S284-S289.
2. Zar HJ, Ferkol TW. The global burden of respiratory disease-
impact on child health. Pediatric Pulmonology 2014; 49:430-
434.
3. Jartti T, Jartti L, Ruuskanen O et al. New respiratory viral
infections. Curr Opin Pulm Med 2012, 18: 271-278.
4. Berry M, Gamieldien J, Fielding B. Identification of new
respiratory viruses in the new millennium viruses 2015; 7:
996-1019.
5. Panda S, Mohakud NK, Pena L et al. Human Metapneumovirus:
review of an important respiratory pathogen. Int J Infect Dis
2014; 25:45-52.
6. Edwards KM, Zhu Y, Griffin MR et al. Burden of Human
Metapneumovirus infection in young children.N Engl J Med
2013; 368(7): 633–643.
7. Van den Hoogen BG, de Jong JC, Groen J et al. A newly
discovered human pneumovirus isolated from young children
with respiratory tract disease. Nat Med 2001;7: 719-724.
8. Jofre L. Virus respiratorios emergentes. Neumología Pediátrica
2007.
http://www.neumologia-pediatrica.cl9. Boivin G, De Serres G, Hamelin ME et al. An outbreak of severe
respiratory tract infection due to Human Metapneumovirus in
a long-term care facility. Clin Infect Dis 2007; 44:1152-1158.
10. Louie JK, Schnurr DP, Pan CY et al. A summer outbreak of Human
Metapneumovirus infection in a long-term-care facility . J
Infect Dis 2007;196:705-708.
11. Principi N, Esposito S. Paediatric Human Metapneumovirus
infection: epidemiology, prevention and therapy. J Clin Virol
2014;59:141-7.
12. Roussy JF, Carbonneau J, Ouakki M et al. Human
Metapneumovirus viral load is an important risk factor for
disease severity in young children. J Clin Virol 2014;60:133-
140.
13. Bosis S, Esposito S, Osterhaus AD et al. Association between high
nasopharyngeal viral load and disease severity in children with
Human Metapneumovirus infection. J Clin Virol 2008:42:286-
290.
14. Yan XL, Li YN, Tang YJ et al. Clinical characteristics and viral load
of Respiratory Syncytial Virus and Human Metapneumovirus in
children hospitaled for acute lower respiratory tract infection. J
Med Virol 2016 Sept 15
15. Darniot M, Pitoiset C, Petrella T, et al. Age-associated
aggravation of clinical disease after primary Metapneumovirus
infection of BALB/c mice. J Virol 2009;83:3323-3332.
16. Semple MG, Cowell A, Dove W et al. Dual infection of infants
by Human Metapneumovirus and Human Respiratory Syncytial
virus is strongly associated with severe bronchiolitis. J Infect Dis
2005;191:382-386.
17. Peng D, Zhao D, Liu J et al. Multipathogen infections in
hospitalized children with acute respiratory infections. Virol J
2009;6-155.
18. Lim FJ, de Klerk N, Blyth CC et al. Systematic review and meta-
analysis of respiratory viral coinfections in children. Respirology
2016;21:648-655.
19. Luchsinger V et al. Detection of Human Metapneumovirus in
children hospitalized for acute lower respiratory infection in
Santiago, Chile. Rev Méd Chile 2005; 133: 1059-64.
20. Kroll JL, Weinberg A. Human Metapneumovirus. Semin Respir
Crit Care Med 2011;32(4):447-53.
21. Butt SA, Maceira VP, McCallen ME et al. Comparison of three
comercial RT-PCR system for detection of respiratory viruses. J
Clin Virol 2014; 61:406-410.
22. Esposito S, Mastrolia V. Metapneumovirus infections and
respiratory complications. Semin Respir Crit Care Med
2016;37(4):512-21.
23. Ren J, Phan T, Bao X. Recent vaccine development for Human
Metapneumovirus. J Gen Virol 2015;96:1515-1520.
24. Jonsdottir H, Dijkman R. Coronaviruses and the human aiway:
a universal system for virus-host interaction studies. Virol J
2016; 13:24.
25. Lu R, Yu X, Wang W, et al. Characterization of Human Coronavirus
etiology in Chinese adults with acute upper respiratory tract
infection by real-time RT-PCR assays. Plos One 2012, 7, e
36638.
26. Walsh E, Shin JH, Falsey A. Clinical impact of Human
Coronaviruses 229E and OC43 infection in diverse adult
population. J Infect Dis 2013;208:1634-1642
27. Zhou W, Wang W, Wang H, et al. First infection by all four
non-severe acute respiratory syndrome Human Coronaviruses
takes places during childhood. BMC Infect Dis 2013, 13,e433.
28. Gaunt ER, Hardie A, Claas ECJ et al. Epidemiology and Clinical
Presentations of the four Human Coronaviruses 229E, HKU1,
NL63 and OC43 detected over 3 years using a novel multiplex
real-time PCR method. J Clin Microbiol 2010;48:2940-2947.
29. Summary of probable SARS cases with onset of illness from 1
November 2002 to 31 July 2003.
http://www.who.int/csr/sars/country/table2004_04_ 21/en/.
30. Hon K, Leung C, Cheng W, et al. Clinical presentations and
outcome of severe acute respiratory syndrome in children.
Lancet 2003;361:1701-1703.
31. Leung C, Kwan Y, Ko P, et al. Severe acute respiratory syndrome
among children. Pediatrics 2004; 113:535-543.
32. De Sousa R, Reusken C, Koopmans M. MERS Coronavirus: Data
gaps for laboratory preparedness. J Clin Virol 2014;59:4-11.
[REV. MED. CLIN. CONDES - 2017; 28(1) 83-89]