270
5. Toro P., Schönknecht P., Schröder J. Type II diabetes in mild
cognitive impairment and Alzheimer’s disease: Results from a
prospective population-based study in Germany. J Alzheimers
Dis 2009, Apr;16(4):687-91
6. Luchsinger J. A. Type 2 diabetes and cognitive impairment:
linking mechanisms. Journal of Alzheimer’s Disease.
2012;30(2):S185–S198.
7. Frolich L, Blum-Degen D, Bernstein HG, Engelsberger S,
Humrich J, Laufer S, et al. P. Brain insulin and insulin receptors
in aging and sporadic Alzheimer’s disease. J Neural Transm.
1998;105:423–438.
8. Small SA, Perera GM, DeLaPaz R, Mayeux R, Stern Y. Differential
regional dysfunction of the hippocampal formation among
elderly with memory decline and Alzheimer’s disease. Ann
Neurol.1999;45:466–472.
9. Peila R, Rodriguez BL, Launer LJ. Type 2diabetes, APOE gene, and
the risk for dementia and related pathologies The Honolulu-
Asia Aging Study. Diabetes.2002;51(4):1256–1262.
10. Muriach M, Flores-Bellver M, Romero FJ, Barcia JM.
Diabetes and the Brain: Oxidative Stress, Inflammation,
and Autophagy. Oxidative Medicine and Cellular Longevity.
2014;2014:102158.
11. Lee JH, Choi Y, Jun C, Hong YS, Cho HB, Kim JE, et al.
Neurocognitive changes and their neural correlates in
patients with type 2 diabetes mellitus. Endocrinol Metab.
2014;29(2):112–121.
12. Willette AA, Bendlin BB, Starks EJ, et al. Association of Insulin
Resistance With Cerebral Glucose Uptake in Late Middle–
Aged Adults at Risk for Alzheimer Disease. JAMA Neurol.
2015;72(9):1013-1020.
13. Li ZG, Zhang W, Sima AA. The role of impaired insulin/IGF
action in primary diabetic encephalopathy. Brain Res. 2005;
1037: 12–24.
14. Tonoli C, Heyman E, Roelands B, Pattyn N, Buyse L, Piacentini
MF, et al. Type 1 diabetes-associated cognitive decline:
a meta-analysis and update of the current literature. J
Diabetes. 2014;6:499–513.
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