15 / 176
659
5. Mashour, G.A., Woodrum, D.T. & Avidan, M.S. Neurological
complications of surgery and anaesthesia. Br J Anaesth 114,
2015; 194-203.
6. Urban, B.W. & Bleckwenn, M. Concepts and correlations relevant
to general anaesthesia. Br J Anaesth 89, 2002; 3-16.
7. Franks, N.P. Molecular targets underlying general anaesthesia.
Br J Pharmacol 147 Suppl 1, 2006; S72-81.
8. Campagna, J.A., Miller, K.W. & Forman, S.A. Mechanisms of
actions of inhaled anesthetics. N Engl J Med 348, 2003; 2110-
2124.
9. Rudolph, U. & Antkowiak, B. Molecular and neuronal substrates
for general anaesthetics. Nat Rev Neurosci 5, 2004; 709-720.
10. Miller’s Anesthesia, Eigth Edition, 2015.
11. Perouansky, M. The quest for a unified model of anesthetic
action: a century in Claude Bernard’s shadow. Anesthesiology
117, 2012; 465-474.
12. Meyer,H.ZurTheoriederAlkoholnarkose.ArchivfürExperimentelle
Pathologie und Pharmakologie 42, 1899; 109-118.
13. Meyer, H. Zur Theorie der Alkoholnarkose. Archiv f. experiment.
Pathol. u. Pharmakol 1901; 46, 9.
14. Meyer, K. Contributions to the theory of narcosis. Trans. Faraday
Soc. 1937; 33, 3.
15. Eger, E.I., 2nd, Saidman, L.J. & Brandstater, B. Minimum alveolar
anesthetic concentration: a standard of anesthetic potency.
Anesthesiology 26, 1965; 756-763.
16. Ueda, I. & Kamaya, H. Kinetic and thermodynamic aspects of the
mechanism of general anesthesia in a model system of firefly
luminescence in vitro. Anesthesiology 38, 1973; 425-436.
17. Franks, N.P. & Lieb, W.R. Do general anaesthetics act by
competitive binding to specific receptors? Nature 310, 1984;
599-601.
18. Raines, D.E. & Miller, K.W. On the importance of volatile agents
devoid of anesthetic action. Anesth Analg 79, 1994; 1031-
1033.
19. Lin, L.H., Chen, L.L., Zirrolli, J.A. & Harris, R.A. General anesthetics
potentiate
γ
-aminobutyric acid actions on
γ
-aminobutyric acid
A receptors expressed by Xenopus oocytes: lack of involvement
of intracellular calcium. J Pharmacol Exp Ther 263, 1992;
569-578.
20. Dwyer, R., Bennett, H.L., Eger, E.I., 2nd & Heilbron, D. Effects of
isoflurane and nitrous oxide in subanesthetic concentrations on
memory and responsiveness in volunteers. Anesthesiology 77,
1992; 888-898.
21. Stoelting, R.K., Longnecker, D.E. & Eger, E.I., 2nd. Minimum
alveolar concentrations in man on awakening from
methoxyflurane, halothane, ether and fluroxene anesthesia:
MAC awake. Anesthesiology 33,1970;5-9.
22. Koblin, D.D., et al. Polyhalogenated and perfluorinated
compounds that disobey the Meyer-Overton hypothesis. Anesth
Analg 79, 1994; 1043-1048.
23. Fang, Z., et al. Effects of inhaled nonimmobilizer, proconvulsant
compounds on desflurane minimum alveolar anesthetic
concentration in rats. Anesth Analg 85,1997;1149-1153.
24. Alkire, M.T., Hudetz, A.G. & Tononi, G. Consciousness and
anesthesia. Science 322, 2008; 876-880 .
25. Bettler, B., Kaupmann, K., Mosbacher, J. & Gassmann, M.
Molecular structure and physiological functions of GABAB
receptors. Physiol Rev 84, 2004; 835-867.
26. Olsen, R.W. & Sieghart, W. International Union of Pharmacology.
LXX. Subtypes of
γ
-aminobutyric acid A receptors: classification
on the basis of subunit composition, pharmacology, and
function. Update. Pharmacol Rev 60, 2008; 243-260.
27. Bonin, R.P. & Orser, B.A. GABAA receptor subtypes underlying
general anesthesia. Pharmacol Biochem Behav 90, 2008;
105-112.
28. Wang, D.S., Penna, A. &Orser, B.A. Ketamine Increases the Function
of
γ
-Aminobutyric Acid Type A Receptors in Hippocampal and
Cortical Neurons. Anesthesiology 126, 2017; 666-677.
29. Farrant, M. & Nusser, Z. Variations on an inhibitory theme: phasic
and tonic activation of GABAA receptors. Nat Rev Neurosci 6,
2005; 215-229.
30. Sigel, E. & Steinmann, M.E. Structure, function, and modulation
of GABAA receptors. J Biol Chem287, 2012; 40224-40231.
31. Forman, S.A. & Chin, V.A. General anesthetics and molecular
mechanisms of unconsciousness. Int Anesthesiol Clin 46, 2008;
43-53.
32. Hemmings, H.C., Jr., et al. Emerging molecular mechanisms
of general anesthetic action. Trends Pharmacol Sci 26, 2005;
503-510.
33. Hill-Venning, C., Belelli, D., Peters, J.A. & Lambert, J.J. Subunit-
dependent interaction of the general anaesthetic etomidate
with the
γ
-aminobutyric acid type A receptor. Br J Pharmacol
120, 1997; 749-756.
34. Jenkins, A., et al. Evidence for a common binding cavity for three
general anesthetics within the GABAA receptor. J Neurosci 21
2001; RC136.
35. Jurd, R., et al. General anesthetic actions in vivo strongly
attenuated by a point mutation in the GABAA receptor
β
3
subunit. FASEB J 17, 2003; 250-252.
36. Jacob, T.C., Moss, S.J. & Jurd, R. GABAA receptor trafficking and its
role in the dynamic modulation of neuronal inhibition. Nat Rev
Neurosci 9, 2008; 331-343.
37. Cheng, V.Y., et al.
α
5GABAA receptors mediate the amnestic
but not sedative-hypnotic effects of the general anesthetic
etomidate. J Neurosci 26, 2006; 3713-3720.
38. Goldstein, S.A., et al. International Union of Pharmacology. LV.
Nomenclature and molecular relationships of two-P potassium
channels. Pharmacol Rev 57, 2005; 527-540.
39. Patel, A.J., et al. Inhalational anesthetics activate two-pore-
domain background K+ channels. Nat Neurosci 2, 1999;
422-426.
40. Lodge, D. & Johnson, K.M. Noncompetitive excitatory amino acid
receptor antagonists. Trends Pharmacol Sci 11, 1990; 81-86.
41. Jevtovic-Todorovic, V., et al. Nitrous oxide (laughing gas) is an
NMDA antagonist, neuroprotectant and neurotoxin. Nat Med 4,
1998; 460-463.
42. Lynch, J.W. Molecular structure and function of the glycine
receptor chloride channel. Physiol Rev 84, 2004; 1051-1095.
[NEUROCIENCIA Y ANESTESIA - Dr. Antonello Penna MD PhD y col.]